Think twice about the cause of frequent nighttime urination.
Nocturia is the need to wake up to urinate during the night; getting up 2 or more times a night may affect up to 70 million adults in the U.S.—22% of the population.1,2
But while many believe the cause of nocturia originates in the bladder or prostate, the true cause may be a lesser-known suspect: nocturnal polyuria (NP), a disease that affects the kidneys, causing overproduction of urine at night.3
Nocturia affects adults of all ages1
A study of over 9000 adults revealed1:
Nocturia can interrupt sleep and disrupt health.
The first nocturia episode often occurs 2 to 3 hours after falling asleep4,5
Patients wake up
throughout the night
Getting up 2 or more times a night worsens the impact3
- Leads to 9.2% greater work impairment vs those without nocturia6
- Associated with a higher likelihood of depression, especially among younger men and women7
- Incidence of fall-related fractures is significantly higher in patients with nocturia8
- Prevalence of hypertension and diabetes increases in men and women with nocturia9
- Increases mortality risk by 54% in men and 28% in women3
Finding out the “Wake Number” (the number of times a patient wakes up to urinate) could be important. See the Wake Number Quiz to learn how it can facilitate a discussion with your patients about frequent nighttime urination.
If frequent nighttime urination occurs,
the kidneys may be to blame.
Nocturnal polyuria is present in up to 88% of nocturia patients.10 It’s the leading cause of nocturia.10-12
What is nocturnal polyuria (NP)?
Nocturnal polyuria occurs when the volume of nighttime urine production by the kidney exceeds14:
of daily urine total in patients <65
of daily urine total in patients >65
A Voiding Diary can help in discussing and evaluating a patient’s frequent nighttime urination.Download a sample Voiding Diary
Up to 88% of nocturia patients have nocturnal polyuria (NP)10*
Nocturnal polyuria is also present in a majority of patients with OAB and/or BPH
of men and women with
OAB also have
of men with
BPH also have
*Based on completed frequency-volume charts.
In the fight against nocturia, the bladder and the prostate aren’t always the right target.
OAB and BPH medications may not be effective because nocturnal polyuria is a condition that affects the kidneys.12
The Patient Wake Number Quiz
After patients click through and answer the 5 questions below, they can print out a completed Wake Number Quiz and use it to discuss their frequent nighttime urination with you.
Learn more about NP—sign up now
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- Vaughan CP, Fung CH, Huang AJ, Johnson TM, Markland AD. Differences in the association of nocturia and functional outcomes of sleep by age and gender: a cross-sectional, population-based study. Clin Ther. 2016;38(11):2386-2393.
- Henry J Kaiser Family Foundation. Total number of residents. https://www.kff.org/other/state-indicator/total-residents/?currentTimeframe=0&sortModel=%7B%22colId%22:%22Location%22,%22sort%22:%22asc%22%7D. Accessed June 13, 2018.
- Oelke M, De Watcher S, Drake MJ, et al. A practical approach to the management of nocturia. Int J Clin Pract. 2017;71(11):e13027:1-11.
- Kim SY, Bang W, Kim MS, Park B, Kim JH, Choi HG. Nocturia is associated with slipping and falling. PLoS One. 2017;12(1):1-9.doi:10.1371/journal.pone.0169690.
- Chapple CR, Batista JE, Berges R, et al. The impact of nocturia in patients with LUTS/BPH: need for new recommendations. European Urology Supplements. 2006;5(1):12-18.
- Kobelt G, Borgström F, Mattiasson A. Productivity, vitality and utility in a group of healthy professionally active individuals with nocturia. BJU Int. 2003;91(3):190-195.
- Kupelian V, Wei JT, O’Leary MP, Norgaard JP, Rosen RC, McKinlay JB. Nocturia and quality of life: results from the Boston area community health survey. Eur Urol. 2012;61(1):78-84.
- Nakagawa H, Niu K, Hozawa A, et al. Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. J Urol. 2010;184(4):1413-1418.
- Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z. Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. Int J Clin Pract. 2015;69(12):1508-1516.
- Weiss JP, van Kerrebroeck PE, Klein BM, Nørgaard JP. Excessive nocturnal urine production is a major contributing factor to the etiology of nocturia. J Urol. 2011;186(4):1358-1363.
- Weiss JP. Nocturia: focus on etiology and consequences. Rev Urol. 2012;14(3-4):48-55.
- Weiss JP, Blaivas JG, Bliwise DL, et al. The evaluation and treatment of nocturia: a consensus statement. BJU Int. 2011;108(1):6-21.
- Yazici CM, Kurt O. Combination therapies for the management of nocturia and its comorbidities. Res Rep Urol. 2015;7:57-63.
- Fine ND, Weiss JP, Wein AJ. Nocturia: consequences, classification, and management. F1000Res. 2017;6(F1000 Faculty Rev):1-7. doi:10.12688/f1000research.11979.1:1-7.
- Brubaker L, FitzGerald MP. Nocturnal polyuria and nocturia relief in patients treated with solifenacin for overactive bladder symptoms. Int Urogynecol J Pelvic Floor Dysfunct. 2007;18(7):737-741.
- Rovner ES, Raymond K, Andruczyk E, Juul KV. Low-dose desmopressin and tolterodine combination therapy for treating nocturia in women with overactive bladder: a double-blind, randomized, controlled study. Low Urin Tract Symptoms. 2017.Epub:1-11. doi:10:1111/luts.12169.
- Singam P, Hong GE, Ho C, et al. Nocturia in patients with benign prostatic hyperplasia: evaluating the significance of ageing, co-morbid illnesses, lifestyle and medical therapy in treatment outcome in real life practice. Aging Male. 2015;18(2):112-117.