Think twice about the cause of frequent nighttime urination.

Nocturia is the need to wake up to urinate during the night; getting up 2 or more times a night may affect up to 70 million adults in the U.S.—22% of the population.1,2

But while many believe the cause of nocturia originates in the bladder or prostate, the true cause may be a lesser-known suspect: nocturnal polyuria (NP), a disease that affects the kidneys, causing overproduction of urine at night.3

Nocturia affects adults of all ages1

A study of over 9000 adults revealed1:

Men with nocturia
Women with nocturia

Nocturia can interrupt sleep and disrupt health.

The first nocturia episode often occurs 2 to 3 hours after falling asleep4,5

Nocturnal polyuria syndrome

Patients wake up
throughout the night
to urinate

Getting up 2 or more times a night worsens the impact3

  • Leads to 9.2% greater work impairment vs those without nocturia6
  • Associated with a higher likelihood of depression, especially among younger men and women7
  • Incidence of fall-related fractures is significantly higher in patients with nocturia8
  • Prevalence of hypertension and diabetes increases in men and women with nocturia9
  • Increases mortality risk by 54% in men and 28% in women3

Finding out the “Wake Number” (the number of times a patient wakes up to urinate) could be important. See the Wake Number Quiz to learn how it can facilitate a discussion with your patients about frequent nighttime urination.

If frequent nighttime urination occurs,
the kidneys may be to blame.

Overactive Bladder (OAB)
What is nocturia
Benign Prostatic Hyperplasia (BPH)
noctguria treatment medications
Nocturnal Polyuria (NP)

Nocturnal polyuria is present in up to 88% of nocturia patients.10 It’s the leading cause of nocturia.10-12

What is nocturnal polyuria (NP)?

With nocturnal polyuria, the kidneys overproduce urine at night, which can lead to frequent nighttime bathroom visits and to serious health problems as well.3,13
Normal 24-hour urine production11
Who suffers from nocturnal polyuria (NP)
Nocturnal polyuria (NP)11
frequent urination in elderly at night

Nocturnal polyuria occurs when the volume of nighttime urine production by the kidney exceeds14:

managing nocturia > 1/5

of daily urine total in patients <65

Peeing too much at night > 1/3

of daily urine total in patients >65

A Voiding Diary can help in discussing and evaluating a patient’s frequent nighttime urination.

Download a sample Voiding Diary

Up to 88% of nocturia patients have nocturnal polyuria (NP)10*

Nocturnal polyuria is also present in a majority of patients with OAB and/or BPH


of men and women with

What causes nocturiaOAB also have

nocturnal polyuria15,16


of men with

BPH also have

nocturnal polyuria17

*Based on completed frequency-volume charts.

Nocturia treatment

In the fight against nocturia, the bladder and the prostate aren’t always the right target.

OAB and BPH medications may not be effective because nocturnal polyuria is a condition that affects the kidneys.12

The Patient Wake Number Quiz

After patients click through and answer the 5 questions below, they can print out a completed Wake Number Quiz and use it to discuss their frequent nighttime urination with you.

What's Causing Me to Urinate a Lot at Night?

If you are experiencing frequent nighttime urination, answer a few questions and share the results with your doctor.

Thanks for taking the time to answer these questions. Take this guide to your doctor and start a conversation.



Waking up during the night to urinate is a condition known as “nocturia.” It may affect up to 70 million adults in the US.

But while many believe the cause of nocturia originates in the bladder or prostate, the true cause may be a lesser-known
suspect: nocturnal polyuria (NP), a disease that affects the kidneys, causing overproduction of urine at night.

If your nighttime urine volume is similar to or more than your
overall daytime urine volume, there’s a strong chance that
nocturnal polyuria (NP) may be the culprit.

Waking up throughout the night to urinate isn’t something you have to live with
—and you are certainly allowed to be bothered. That's why you should talk to your doctor.
Reducing the amount of liquids you consume before bedtime is a good
place to start. However, this may not fully address the underlying problem.
Talk to your doctor about medications you are currently taking or have taken in the past.

Voiding Diary

The Voiding Diary is another tool you can use to evaluate a patient’s urinary problem. Print these pages, share them with appropriate patients, and have a discussion about how the Voiding Diary can help.

Learn more about NP—sign up now

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  1. Vaughan CP, Fung CH, Huang AJ, Johnson TM, Markland AD. Differences in the association of nocturia and functional outcomes of sleep by age and gender: a cross-sectional, population-based study. Clin Ther. 2016;38(11):2386-2393.
  2. Henry J Kaiser Family Foundation. Total number of residents.,%22sort%22:%22asc%22%7D. Accessed June 13, 2018.
  3. Oelke M, De Watcher S, Drake MJ, et al. A practical approach to the management of nocturia. Int J Clin Pract. 2017;71(11):e13027:1-11.
  4. Kim SY, Bang W, Kim MS, Park B, Kim JH, Choi HG. Nocturia is associated with slipping and falling. PLoS One. 2017;12(1):1-9.doi:10.1371/journal.pone.0169690.
  5. Chapple CR, Batista JE, Berges R, et al. The impact of nocturia in patients with LUTS/BPH: need for new recommendations. European Urology Supplements. 2006;5(1):12-18.
  6. Kobelt G, Borgström F, Mattiasson A. Productivity, vitality and utility in a group of healthy professionally active individuals with nocturia. BJU Int. 2003;91(3):190-195.
  7. Kupelian V, Wei JT, O’Leary MP, Norgaard JP, Rosen RC, McKinlay JB. Nocturia and quality of life: results from the Boston area community health survey. Eur Urol. 2012;61(1):78-84.
  8. Nakagawa H, Niu K, Hozawa A, et al. Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. J Urol. 2010;184(4):1413-1418.
  9. Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z. Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. Int J Clin Pract. 2015;69(12):1508-1516.
  10. Weiss JP, van Kerrebroeck PE, Klein BM, Nørgaard JP. Excessive nocturnal urine production is a major contributing factor to the etiology of nocturia. J Urol. 2011;186(4):1358-1363.
  11. Weiss JP. Nocturia: focus on etiology and consequences. Rev Urol. 2012;14(3-4):48-55.
  12. Weiss JP, Blaivas JG, Bliwise DL, et al. The evaluation and treatment of nocturia: a consensus statement. BJU Int. 2011;108(1):6-21.
  13. Yazici CM, Kurt O. Combination therapies for the management of nocturia and its comorbidities. Res Rep Urol. 2015;7:57-63.
  14. Fine ND, Weiss JP, Wein AJ. Nocturia: consequences, classification, and management. F1000Res. 2017;6(F1000 Faculty Rev):1-7. doi:10.12688/f1000research.11979.1:1-7.
  15. Brubaker L, FitzGerald MP. Nocturnal polyuria and nocturia relief in patients treated with solifenacin for overactive bladder symptoms. Int Urogynecol J Pelvic Floor Dysfunct. 2007;18(7):737-741.
  16. Rovner ES, Raymond K, Andruczyk E, Juul KV. Low-dose desmopressin and tolterodine combination therapy for treating nocturia in women with overactive bladder: a double-blind, randomized, controlled study. Low Urin Tract Symptoms. 2017.Epub:1-11. doi:10:1111/luts.12169.
  17. Singam P, Hong GE, Ho C, et al. Nocturia in patients with benign prostatic hyperplasia: evaluating the significance of ageing, co-morbid illnesses, lifestyle and medical therapy in treatment outcome in real life practice. Aging Male. 2015;18(2):112-117.